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宜聯(lián)生物完成3.5億元A輪融資，ADC賽道持續(xù)火熱

來(lái)源：藥智網(wǎng)|森林

3月1日，蘇州宜聯(lián)生物醫(yī)藥有限公司近期宣布，已在兩個(gè)月內(nèi)相繼完成總計(jì)3.5億元人民幣的A輪（包括A1和A2輪）融資。A1輪融資由杏澤資本領(lǐng)投；A2輪融資由正心谷資本和啟明創(chuàng)投聯(lián)合領(lǐng)投，杏澤資本進(jìn)一步追加投資。本次A輪融資所募集資金將用于公司新一代抗體偶聯(lián)藥物(ADC)產(chǎn)品管線的開(kāi)發(fā)以及新型偶聯(lián)藥物研發(fā)平臺(tái)的建立。

據(jù)了解，宜聯(lián)生物成立于2020年，聚焦ADC藥物的研發(fā)。宜聯(lián)生物的創(chuàng)始人、CEO薛彤彤博士曾任科倫博泰總經(jīng)理，在生物藥和小分子產(chǎn)品的研發(fā)、商業(yè)化、以及國(guó)內(nèi)外商務(wù)合作方面均擁有較豐富的經(jīng)驗(yàn)；CSO蔡家強(qiáng)博士在小分子和偶聯(lián)技術(shù)開(kāi)發(fā)方面有近30年的經(jīng)驗(yàn)，歷任上海翰森藥業(yè)副總經(jīng)理、Merck英國(guó)研發(fā)中心高級(jí)研發(fā)組長(zhǎng)，先后領(lǐng)導(dǎo)、負(fù)責(zé)超過(guò)100個(gè)項(xiàng)目的研發(fā)工作。

抗體-藥物偶聯(lián)物（antibody-drug conjugates, ADCs）就是通過(guò)化學(xué)反應(yīng)，把傳統(tǒng)的小分子抗癌藥物與重組單克隆抗體（mAb）分子通過(guò)連接分子（linker）結(jié)合，所形成的新分子（圖1）。通常來(lái)說(shuō)，這些mAbs分子都能特異性識(shí)別腫瘤特異性抗原，所以ADC技術(shù)的主要目的就是賦予一些傳統(tǒng)小分子抗癌藥物主動(dòng)靶向的功能。

ADC藥物主要應(yīng)用于抗腫瘤領(lǐng)域，是近年來(lái)熱門的研究方向之一。2000年首個(gè)ADC藥物批準(zhǔn)上市，截至目前已有10個(gè)ADCs產(chǎn)品獲FDA批準(zhǔn)上市， 2019-2020 這兩年共有 6 款產(chǎn)品獲批，其中較早上市的 Adcetris 和 Kadcyla 在 2019 年的銷售額分別為 10.81 億美元和 15.72 億美元，已成為“重磅炸彈”產(chǎn)品。此外，Polivy, Enhertu 和 Trodelvy 也有成為重磅炸彈的潛力。

我國(guó)關(guān)于ADCs的研究起步較晚，目前進(jìn)展最快的品種是榮昌生物的緯迪西妥單抗，已于2020年8月提交上市申請(qǐng)。就目前已披露項(xiàng)目來(lái)看，我國(guó)ADCs藥物的靶點(diǎn)較為集中，大多為已有上市許可產(chǎn)品的同靶點(diǎn)或單抗產(chǎn)品常用靶點(diǎn)，在小分子藥物端、連接物分子和偶聯(lián)方式也少有創(chuàng)新報(bào)道。國(guó)內(nèi)從事ADC藥物開(kāi)發(fā)的企業(yè)大多從單抗等其他生物藥業(yè)務(wù)轉(zhuǎn)化而來(lái)，近連兩年來(lái)產(chǎn)生了幾個(gè)專注于ADC技術(shù)領(lǐng)域的公司，如邁百瑞、聯(lián)寧生物、諾靈生物、啟德醫(yī)藥、多禧生物等。

本文來(lái)源：藥智作者：小編
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